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Morinda officinalis extract

Model: 10:1,20:1, 50:1 TLC

 Morinda officinalis extract
Latin name: Radix Morindae Officinalis
Other names: Morinda Root / Medicinal Indian mulberry Root, Ba ji tian
Part usedRoot
Specification: 10:1,20:1, 50:1 TLC
Appearance : Brownish yellow fine powder
Partical size: 100% pass 80 mesh
Function: Enhance male sexual function

Brief Introduction
Morinda Officinalis can be found in East China. Traditionally, it has been used for certain kidney and
 sexual conditions such as impotence, premature ejaculation, frequent urination, incontinence, weakness, chronic inflammation of nerves, muscular atrophy, and rheumatoid arthritis. It contains morindin, vitamin C,asperuloside tetraacetate, resin, monotrpein, isoalizarins, rubiadian, rubiadin-1-
methyl-ether, anthraquinones, acid, simple sugars and some minerals.
Components
Identified active ingredients include: Rubiadin, rubiadin-1-methyl-ether, methyl-ether from Radix et Rhizoma Rhei, monotropein, tetraacetylasperuloside, β-sitosterol, palmitic acid, nonadecalkane
  and dimethyl-alkane. Radix Morindae Officinalis also contains monosaccharides, polysaccharides, resin, vitamin C, 11 free amino acids and 17 amino acid hydrolysates.
The cortex of Radix Morindae Officinalis (pic.a) contains reducing sugars and glycosides, cardiac glycosides, flavones, triterpenoid steroids, amino acids, organic acids, micro-anthraquinone and metal elements. More abundant microelements include potassium (K), calcium (Ca) and magnesium (Mg). The lead content in the cortex is lower than in the root core (pic.b). Other elements like iron (Fe), manganese (Mn), zinc (Zn) and 16 others are higher in the cortex than in the root core.
Indications in TCM
A. Deficiency of kidney yang
It is indicated for impotence, seminal emission, sterility due to cold in womb, frequent urination, cold and pain in lumbar and knees and other symptoms caused by kidney yang deficiency, because it can tonify kidney yang, strengthen tendons and bones, and it is warm and sweet without dryness in properties. For it is mild in actions of tonifying kidney yang, it is combined with other herbs to tonify. For impotence and sterility due to kidney yang deficiency, insufficiency of fire of life gate, it is combined with kidney-yang-tonifying and kidney-essence-supplementing herbs, for instance, it is used with Yin Yang Huo, Xian Mao, Shu Di Huang and Gou Qi Zi in the formula Zan Yu Wan from Jing Yue Quan Shu. For deficiency cold in lower energizer, sterility due to cold in womb, irregular menstruation and cold-pain in abdomen, it is combined with herbs of warming kidney and liver, dispelling cold and relieving pain, for instance, it is used with Rou Gui and Gao Liang Jiang in the formula Ba Ji Wan from Tai Ping Hui Min He Ji Ju Fang.
B. Wind-damp arthralgia
It is very suitable for chronic arthralgia, weak tendons and bones due to the disease affecting liver and kidney, or kidney yang deficiency with weak tendons and bones attacking by arthralgia, because it can dispel wind-damp, tonify kidney yang, and strengthen tendons and bones. It is commonly combined with herbs of tonifying kidney and liver, strengthening tendons and bones, and dispelling wind-damp. For flaccidity of bones, soreness and limpness of lumbar and knees, it is combined with Du Zhong, Rou Cong Rong, Tu Si Zi and Bi Xie in the formula Jin Gang Wan from Zhang Shi Yi Tong. For excessive inner cold-damp, atrophy-flaccidity of tendons and bones, cold and pain of lumbar and knees, it is combined with Fu Zi and Niu Xi in the formula Ba Ji Wan from Sheng Hui Fang.
Pharmacological Actions
1. Effects on Reproductive Organs 
Animal studies 
A 30g/kg/day dose of Radix Morindae Officinalis decoction was administered to castrated mice once a day for 15 days. Results showed that the weights of levator ani muscles, seminal vesicle and prostate were not significantly effected.
Female rats, administered with 20g/kg Radix Morindae Officinalis decoction twice a day by gavage for five days, showed increments in weights of the ovaries, uterus and pituitary glands. Blood luteinizing hormone (LH) levels were unchanged. However, the binding affinity of HCG/LH receptors and the number of HCG/LH receptors were both increased. Consequently, the value for dissociation constant (Kd) increased when compared to the control group. When rats were injected with LRH, LH secretion was enhanced. After 90 minutes, plasma LH level raised to 51.20ng/ml.
2. Effects on Stress Response
Animal studies
When 20g/kg Radix Morindae Officinalis decoction was given once per day to mice by gavage, for 11 consecutive days, it was shown that the body weights of the mice were increased, and that they could swim for a longer duration of time.
When 5, 10 and 50g/kg/day of Radix Morindae Officinalis infusion was given for eight consecutive days, it did not have the ability to prolong the lifespan of rats whose adrenal glands had been previously removed. 
3. Effects on Thymus Glands 
Animal studies 
When immature mice were orally administered with 64 and 80g/kg of Radix Morindae Officinalis warm water extracts, or 60g/kg of an ethanol extract, or injected i.p. with 10g/kg of a warm water extract once a day for four consecutive days, it was noticed that their mammary glands became atrophic. However, when mature mice were administered 20g/kg Radix Morindae Officinalis decoction by gavage once a day for 11 days, the thymus gland weight and white blood cell count increased. Radix Morindae Officinalis was also able to restore depressed white cell counts in gamma-radiated mice. 
4. Toxicity 
Acute toxicity: Mice were fed with 50g/kg Radix Morindae Officinalis decoction four times a day. The accumulated dose was 250g/kg. Mice were then observed for three days. No animal death was observed.
Genotoxicity: Using the SOS chromotest, it was shown that Radix Morindae Officinalis decoction had no mutagenic or genotoxic effects on Escherichia Coli PQ37 DNA. 
 

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