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Reishi mushroom extract


“The mushroom of immortality”—Ganoderma Lucidum/Duanwood Reishi Extract

【English name】: Reishi Mushroom Extract/Ganoderma lucidum extract

【Latin name】: Ganoderma lucidum (Leysser.Fr)Karst

【Plant part used】: mycelium& fruiting body

【Testing methods】: UV&HPLC

【CAS No.】: Polysaccharide, 9012-72-0; Triterpenoid, 81907-62-2.

【Appearance】: Brownish fine powder

【Particle size】: 100% pass 80 mesh

【Main Function】: Stimulate Immune System and Anti-Cancer

Chemical composition

Researchers have identified three specific compounds that are essential to Reishi’s powerful antioxidant and antiaging effects:

Polysaccharides have anticancer effects based on their ability to prevent abnormal blood vessel formation, and to boost immune system function.

Beta glucan can enhance the immune system. It promotes the healing powers of human bodies and leads to prevention of diseases.

Triterpenes protect the liver, lower blood pressure and cholesterol, prevent platelet clumping that leads to heart attack and stroke, fight allergic responses triggered by histamine, and also possess anticancer activity.


Ratio Extract: 10:1, 20:1, 50:1TLC 

Standard Aqueous Extract:

Polysaccharide 10%, 20%, 30%, 40%, 50% UV

Polysaccharide 10%; Triterpenoid 1% HPLC

Polysaccharide 20%; Triterpenoid 2% HPLC

Polysaccharide 30%; Triterpenoid 2% HPLC

Polysaccharide 40%; Triterpenoid 1% HPLC

Polysaccharide 50%; Triterpenoid 1% HPLC 

BETA D Glucan 30% UV; Triterpenoid 2% HPLC

BETA D Glucan 50% UV; Triterpenoid 1% HPLC

Standard Aqueous & Ethanol Extract:

Polysaccharide 10% UV, Triterpenoid 4% HPLC

Polysaccharide 10% UV, Triterpenoid 6% HPLC

Polysaccharide 10% UV, Triterpenoid 8% HPLC

The Actions of Reishi Polysaccharides

Reishi is officially listed as a substance for treating cancer by the Japanese government.In comparison to its other properties, Reishi has received the most attention as a source of antitumor activity. This action is due to immunostimulating polysaccharides, particularly those known as Beta-D-Glucans. 

Dr. Fukumi Morishige, M.D., Dr. Med. Sci., Ph.D., a former heart surgeon and cancer surgeon, did extensive research on the action of Reishi on the immune system. He gave two groups of patients Reishi extracts. In those patients who had shown high readings of immunoglobulins (IgA, IgG, IgE, IgM), their counts had lowered, while those who previously had low counts now showed the same antibodies in higher counts. 

In 1979, researchers in Poland found that an RNA from Reishi disrupts viral diseases by inducing the production of interferon. This RNA was found in the fruit body of Reishi and in higher levels in the mycelium. 

Reishi Polysaccharides increase RNA and DNA in the bone marrow where immune cells such as lymphocytes are made. One of the active polysaccharides is called D6. Researchers in Beijing injected it into mice for a week and then monitored the changes in DNA and RNA in the bone marrow. Increases were roughly 50%. Protein in bone marrow also increased by as much as 28.5%. It is in the bone marrow that the body manufactures B-cells which in turn produce antibodies. It is also where macrophages have some of their earliest beginnings. 

Investigators in China found that the polysaccharide part of Reishi causes a marked increase in the action of macrophages to gobble up foreign cells in the abdomen of mice. Dr. Morishige discovered that vitamin C renders the high molecular weight polysaccharides into oligoglucans of molecular weight about 30,000. He explains that once the oligoglucans are dissolved in the bloodstream, the macrophage, which normally rests until late in the war on abnormal and foreign cells, is called into action at an earlier stage of the battle. 

Reishi polysaccharides also augments the responsiveness of antibodies, particularly IgG, by expanding the "memory" of T-cells. IgG constitutes a major class of antibodies in human serum that act to enhance phagocytosis (the cell-gobbling action of certain immune cells) and neutralize toxins. 

AIDS treatment news, a newsletter out of San Francisco, talks about research conducted on Fu Zheng treatment of AIDS by Dr. Subhuti Dharmananda and his group. Reishi is one of the herbs that appears to be used successfully.

Beta Glucan:

"Beta Glucan" is one of polysaccharide polymer which is formed by combining various amounts of glucose sugars. When sugar conjuncts, there are Alpha and Beta types of structures. The polysaccharide polymer which is formed by Beta type structure is known as Beta glucan.

Mushrooms originally contain large amount of Beta glucan. Agaricus subrufescens, fomes yucatensis and sparassis erispa and etc are renowned for it. Among all of these, Ganodermoa is especially reputed to contain abundant amount of Beta glucan. ​

Beta glucan can enhance the immune system. It promotes the healing powers of human bodies and leads to prevention of diseases. Its healing effects can help treatment of cancer, viruses, hypoglycemic, viruses, blood pressure regulation, allergy improvement and also restore our bodies to a state of being full of energy and vitality which helps us to be socially healthy in our relations with other people.


Triterpeniods, also called Ganoderic acids which is another major active constituent found in red reishi. Preliminary studies indicated that ganoderic acids help alleviate common allergies by inhibiting histamine release, improve oxygen utilization and improve liver functions. Triterpeniods are bitter in taste and the level of the triterpeniod content contained in a product can be determined by the bitterness.Users of Ginkgo Biloba, Horse Chestnut and Valerian will recognize the potential benefits of terpenes.  

The potency of Reishi mushrooms is usually based on its level of triterpenoids. One can determine the level of this by tasting it. The more bitter it is, the higher the level of triterpenoids. Because Reishi is a polypore, (a group of hard, woody, bracket-like mushrooms) it is not eaten, but cut into pieces and made into a tea. In China, the average dose is 3 to 5 grams a day. Other popular forms of delivery are the water/alcohol extracts and powders.  

For these people it should come as little surprise that the triterpene-rich reishi mushroom is reputed to reduce hypertension. What may be news, however, is that the same compounds may also be adaptogenic and anti-allergic. The Ganoderic acids, C, A and D--in that order--appear to have the greatest anti-allergic activity, inhibiting histamine release. Ganoderic acids B and D may reduce hypertension. Studies done on a combination formula of reishi and other ganoderma species have shown these anti-allergic effects to be perhaps this medicinal's most promising property. The combination formula has been observed to have a modulating and stabilizing effect on immunoglobulin levels. Patients with bronchitis, bronchial asthma, and allergies have all done well on reishi extract. Triterpene content may explain reishi's ability to alleviate altitude sickness, as reported by Chinese mountain climbers ascending as high as 17,000 ft.

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