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Isolated Icariin 98% HPLC

Model: Icariin 98%

 Horny Goat Weed Extract with Icariin 98% HPLC 

【 English Name】: Horny Goat Weed/Epimedium Extract

【 Specification】: Icariin 98% HPLC

【 Plant Part Used】: Branches and Leaves.

【 Solubility: soluble in ethanol. Soluble excellent in alcoholic drink.

【 Appearance 】: Light greenish yellow fine powder.

【 Particle size 】: 100% pass 80 meshes. 

The Actions of Icariin

MALE SEXUAL ENHANCEMENT

Growing body of research shows that isolated Icariin inhibits the enzyme phosphodiesterase-5(PDE-5)and significantly increase nitric oxide synthase, helping to improve erectile function in multiple models. Studies also indicate that isolated Icariin increase circulating testoserone levels. However, unlike prescription medications, epimedium does not work in an hour or two. It normally takes several days for the sexual benefits to be noticed.

IMMUNE ENHANCEMENT

Studies suggest that isolated Icariin plays a role in immune enhancement via the regulation of various hormone pathways. Specifically, research indicates estrogenic-type activity in female breast cell lines, inhibiting properties in male prostate cell lines, as well as testosterone mimetic properties.

ANTI-DEPRESSANT

Recent findings point to an important role for isolated Icariin in the mitigation of symptoms associated with depression. In particular, isolated Icariin has been shown to reduce know stress-induced triggers, such as brain monoamine oxidase A&B,serum corticotropin-releasing factor, and cortisol.

BONE HEALTH & DENSITY

Ongoing research reveals that isolated Icariin can improve bone health markers. Both in vivo and in vitro studies show that it enhances osteoblast(cells responsible for bone formation) activity and suppresses osteoclast(cells that breakdown bone)activity, even in postmenopausal women.

CARDIOVASCULAR HEALTH

A wide range of studies show that isolated Icariin can help to regulate cAMP/cGMP levels, and significantly increase endogenous NO(nitric oxide) generation. Furthermore, research indicates that it can produce No-dependent relaxation in coronary artery, and enhance endothelial function.

ANTIOXIDANT

Studies show that, from a kinetic standpoint, isolated Icariin is a far more effective antioxidant than know antioxidants such as vitamins E and C. Most important, however, isolated Icariin is demonstrated to significantly increase naturally-occurring levels of super antioxidant, SOD(superoxide sismutase). 

Safety

It is interesting to note that although at least 15 fifteen active compounds have been identified in epimedium extracts, (luteolin, icariin, quercetin, and various epimedins), many supplement companies currently use alcohol extracts standardized only for high levels of icariin. The traditional use of epimedium, however, is as a hot-water decoction (tea), which would result in a very different profile of active constituents when compared to the high-icariin alcohol extracts that are more commonly used in commercial products. Although at least one test test-tube study has shown icariin to protect liver cells from damage with by various toxic compounds, other feeding studies (in rodents) have suggested that high-dose icariin may be associated with kidney and liver toxicity.

Scientific support

Isolated Icariin Has Been Studies by Researchers At:

UNITED STATES-Published research conducted in America, as well as Asia and Europe, by highly-respected scientists, shows that the flavonoid compound icariin exhibits significant efficacy and may be of pronounced benefit for a number of health concerns.

Flavonoids are the compounds contained in vegetables, fruits, teas and red wines, that are believed to provide their meaningful health benefits-including supporting cardiovascular function, and immune system function.

As a flavonoid, Icariin is by definition a plant metabolite with inherent antioxidant activity. But unlike typical flavonoid compounds, Icariin appears to clearly be at the head its class and the shining star in this important class of chemicals.

Testing shows that isolated Icariin-which has been separated and elucidated from the group of flavonoids known as "Icariins"-is much more selective and markedly more potent than other flavonoids.

Derived from the plant genus Epimedium, Icariin has separatedly been shown in well constructed testing to promote normal erectile function in multiple models, enhance immune function, reduce the symptoms associated with certain types of depression, support bone health and density, and promote cardiovascular health, among other promising scientifically validates uses.

Icariin research has been reported in such noteworth medical and scientific journals as: Urology,Asian Journal of Andrology, International Journal of Impotence Research, Life Sciences, Clinical and Experimental Pharmacology&Physiology, Vascular Pharmacology, Phytomedicine, Journal of Cardiovascular Pharmacology, journal of Bone&Mineral Research, European Journal of Pharmacology.

Human studies

As of 2013, we could only find one human study with epimedium herb. Effect of Epimedium sagittatum on quality of life and cellular immunity in patients of hemodialysis maintenance; Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995.

Our previous study had demonstrated this Chinese medicine exerted immuno-enhancing effect on the animal model of chronic renal insufficiency. In present study, we investigated the therapeutic effect of Epimedium Sagittatum on patients of hemodialysis maintenance. 22 cases of regular hemodialytic patients were treated with this herb in the form of decoction. 12 patients with hemodialysis were served as controls. It was found that Epimedium Sagittatum had sexual potentiation effect and improved the quality of life in the patients of chronic renal failure with regular hemodialysis. Interleukin 2 (IL-2) activity of peripheral blood monocytes stimulated by PHA was increased significantly in the patients treated with the herbal preparation. It is suggested that this Chinese medicine had therapeutic effect on sexual disorder and immunologic inadequacy in the patients of chronic renal failure undergoing hemodialysis.

Animal studies

Osteoporosis

Prevention of bone loss by aqueous extract of Epimedii sagittatum in an ovariectomized rat model of osteoporosis.

Zhong Xi Yi Jie He Xue Bao. 2006; Department of Pharmacy, Yueyang Hospital of Chinese Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

To investigate the prevention effect of aqueous extract of Epimedii sagittatum on ovariectomy-induced bone loss in rats. Our findings assessed on the basis of biochemical test, bone mineral density and histomorphometric parameters show that aqueous extract of Epimedii sagittatum has a definite antiosteoporotic effect and can prevent the ovariectomy-induced bone loss in rats.

In vitro studies

An in vitro study means that the evaluation was done in a lab not using any animals or humans.

Effect on cartilage

Effect of five species of Epimedium on growth of cartilage and proliferation of cartilage cell in vitro;Zhongguo Zhong Yao Za Zhi. 2006.

To observe the effect of Epimedium brevicornum, E. sagittatum, E. koreanum, E, wushanense and E. elongntum on the growth of cartilage and proliferation of cartilage cell in vitro. E. brevicornum and E. sagittatum can improve the growth of cartilage and proliferation of cartilage cell in vitro. The other three Epimedium species did not have the same effect.

Osteoporosis and bone health

Effects of rat serum containing total flavonoid extract of Epimedium sagittatum on development of osteoblasts;Zhongguo Zhong Yao Za Zhi. 2008; Department of Pharmacy, Lanzhou General Hospital, PLA, Lanzhou, China.

To investigate the effects of total flavonoid extract of Epimedium sagittatum on the proliferation and differentiation of newborn rat calvarial osteoblasts. Flavonoids from this herb have anti-osteoporosis properties. The flavonoid icariin may be largely responsible for these benefits.

Packing

1)1KG, 2KG, 5KG/bag; packed in an aluminum foil bag outside; double-layer PE inside. 

2)25KG/drum;Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 350mm diameter).

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We also have Icariin 1-98% HPLC; Icariins 10-60% HPLC; Total flavon 10%, 20%, 30% UV.horny goat weed extract 10:1,20:1TLC

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